主讲人：张云峰研究员，中国科学院动物研究所

报告时间：2025年6月17日下午15：00

报告地点：下沙校区食品学院257报告厅

报告人简介：

张云峰，博士，中国科学院动物研究所, 研究员，博士生导师； 2022年9月入选中国科学院相关人才计划、担任农业虫害鼠害综合治理研究国家重点实验室-动物行为与神经编码研究组组长 (独立PI)。北京朝阳区“凤凰计划”高层次人才。

主要从事动物行为调控的神经编码机制研究。人类大脑计划-中国实验室核心骨干成员 (2013-2016；中国唯一参与此项目的实验室)。美国化学感官协会会员，美国化学感官协会Polak青年科学家奖获得者。Physiology & Behavior杂志特邀编委，Current Zoology杂志编委，Animal Research and One Health (AROH)杂志和Sensory Neuroscience杂志首届青年编委，中国动物学会理事，中国动物学会动物行为学分会委员兼副秘书长，中国认知科学学会化学感知分会副秘书长, 中国认知科学学会化学感知分会副秘书长。主持国家重点研发计划课题、国家自然科学青年和面上基金等项目，发表论文40余篇，主要研究成果发表于Nature Neuroscience, Nature Communications, Journal of Neuroscience等刊物。

摘要：

The olfactory system plays a crucial role in mediating instinct behaviors in animals. The olfactory tubercle (OT), as a sub-region of the olfactory sensory cortex, is also one key component of the ventral striatum. The ventral striatum contains islands of Calleja, clusters of dopamine D3 receptor-expressing granule cells, predominantly in the OT. However, the precise neural circuits underlying how these D3 neurons orchestrating instinct behaviors remain elusive. Combing of in vivo and ex vivo electrophysiology, optogenetics, chemogenetics, virus-guided neural circuit tracing, and multiple behavioral assays, we show that optogenetic activation of OT D3 neurons robustly initiates self-grooming in mice while suppressing other ongoing behaviors. Conversely, optogenetic inhibition of these neurons halts ongoing grooming, and genetic ablation reduces spontaneous grooming. Moreover, at the neural circuit level, OT D3 neurons show increased activity before and during grooming and influence local striatal output via synaptic connections with neighboring OT neurons (primarily spiny projection neurons, SPNs). Additionally, we demonstrate that mice exhibit social preference for conspecifics that groom more regardless of biological sex. Furthermore, we reveal that ablation or inhibition of these D3 neurons leads to depression-like behaviors, whereas their activation ameliorates chronic restraint stress (CRS)-induced depression-like behaviors, highlighting the crucial role of OT D3 neurons in bidirectionally mediating depression-like behaviors. Collectively, OT D3 neurons function versatilely via its intricate orchestrations not only on asocial behavior (self-grooming) but also on social behavior, as well as affective behavior in mice.