报告题目：Dietary Organosulfur-Containing Compounds: Stability and Biological Activities

主讲人：Lu Yuyun (逯与运) 高级研究员，Department of Food Science and Technology, National University of Singapore (新加坡国立大学)

报告时间：7月29日上午10:30

报告地点：下沙校区食品学院257学术报告厅

报告人简介：

Yuyun Lu is a Senior Research Fellow of the Department of Food Science and Technology at the National University of Singapore (NUS). He works on tropical fruit wines and beverage fermentation; valorization of food processing side streams; dietary bioactive compounds (e.g. dietary organosulfur containing compounds, starch hydrolase inhibitors) in edible plants and/or fruits; as well as Foodomics analysis of fermented samples. He has published more than 70 scientific papers.

报告摘要：

Dietary organosulfur-containing compounds (DOSCs) in fruits and vegetables may hold the key to the health-promotion benefits of these foods. Yet their action mechanisms are not clear, partially due to their high reactivity, which leads to the formation of complex compounds during postharvest processing. Among postharvest processing methods, thermal treatment is the most common way to process these edible plants rich in DOSCs, which undergo complex degradation pathways with the generation of numerous derivatives over a short time. At low temperatures, DOSCs are biotransformed slowly during fermentation to different metabolites (e.g., thiols, sulfides, peptides). Interestingly, the complexity of the DOSCs from different food sources seems to be able to converge to similar health benefits, suggesting that there might be a common action mechanism, and hydrogen sulfide (H2S) donation was suggested to be one possibility. Moringin (rhamnobenzyl isothiocyanate) is a major bioactive compound in moringa seeds, which have been used as a healthy food. We investigated moringin and its structurally similar analogues, including benzyl isothiocyanate and 4-hydroxylbenzyl isothiocyanate, for their H2S releasing activity triggered by cysteine. These isothiocyanates rapidly formed cysteine adducts, which underwent intramolecular cyclization followed by slowly releasing (a) organic amine and raphanusamic acid and (b) H2S and 2-carbylamino-4,5-dihydrothiazole-4-carboxylic acids. The product distributions are highly dependent on para-substituents on the phenyl group. Moringin has higher cytotoxicity to cancer cells and is a more potent anti-inflammatory agent than benzyl and hydroxybenzyl analogues, while benzyl isothiocyanate is a better antibacterial agent.

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